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Translational medicine in hepatocellular carcinoma
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《医学前沿(英文)》 2012年 第6卷 第2期 页码 122-133 doi: 10.1007/s11684-012-0193-7
Hepatocellular carcinoma (HCC) is a highly complex disease that is generally resistant to commonly used chemotherapy and radiotherapy. Consequently, there is an urgent need for the development of new treatment strategies for this devastating disease. In the past decade, tremendous progress has been achieved in the molecular stratification of HCCs for diagnosis, prognosis, and therapeutic decision-making. To date, the molecular classification of HCCs has been carried out through transcriptomic, genetic and epigenetic profiling of tumors. Such research has led to identification of several potential molecular targets in HCC, and subsequently, development of novel systemic agents for the treatment of HCC has begun in earnest. In this article, we review the current knowledge of the molecular pathogenesis of HCC and outline potential areas for application of this knowledge in a clinical setting. As a typical virus and inflammation-associated cancer, both host immune response and tumor microenvironment have crucial roles in HCC pathogenesis. In addition, we examine the potential of immunotherapy and strategies targeting various components of the tumor microenvironment, as well as novel molecular and cellular targets in HCC such as cancer stem cells.
关键词: hepatocellular carcinoma molecular classification molecular targeted therapies tumor microenvironment immunotherapy
Molecular classification and molecular targeted therapy of cancer
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《医学前沿(英文)》 2013年 第7卷 第2期 页码 147-149 doi: 10.1007/s11684-013-0274-2
Molecular markers and pathogenically targeted therapy in non-small cell lung cancer
Bo PENG BA , Jinnong ZHANG MD , Jamile S. WOODS MD , Wei PENG MD, PhD
《医学前沿(英文)》 2009年 第3卷 第3期 页码 245-255 doi: 10.1007/s11684-009-0044-3
关键词: lung cancer carcinoma non-small cell lung cancer molecular markers targeted therapy
Pengming SUN PhD, MD , Jalid SEHOULI PhD, MD , Lihui WEI BM ,
《医学前沿(英文)》 2009年 第3卷 第3期 页码 256-264 doi: 10.1007/s11684-009-0052-3
关键词: target therapy gynecologic malignant tumors clinical trail molecular medicine
Liangqian Tong, Ming Zhao, Shu Zhu, Jing Chen
《医学前沿(英文)》 2011年 第5卷 第4期 页码 379-387 doi: 10.1007/s11684-011-0162-6
关键词: nanoparticles superparamagnetic iron oxide targeted therapy molecular imaging cancer
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《医学前沿(英文)》 2013年 第7卷 第2期 页码 157-171 doi: 10.1007/s11684-013-0272-4
Non-small-cell lung cancer (NSCLC) is the most common cause of premature death among the malignant diseases worldwide. The current staging criteria do not fully capture the complexity of this disease. Molecular biology techniques, particularly gene expression microarrays, proteomics, and next-generation sequencing, have recently been developed to facilitate effectively its molecular classification. The underlying etiology, pathogenesis, therapeutics, and prognosis of NSCLC based on an improved molecular classification scheme may promote individualized treatment and improve clinical outcomes. This review focuses on the molecular classification of NSCLC based on gene expression microarray technology reported during the past decade, as well as their applications for improving the diagnosis, staging and treatment of NSCLC, including the discovery of prognostic markers or potential therapeutic targets. We highlight some of the recent studies that may refine the identification of NSCLC subtypes using novel techniques such as epigenetics, proteomics, or deep sequencing.
关键词: non-small-cell lung cancer molecular typing individualized medicine molecular-targeted therapy gene expression profiling
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《医学前沿(英文)》 2015年 第9卷 第2期 页码 134-138 doi: 10.1007/s11684-015-0396-9
Drug resistance is a major factor that limits the efficacy of targeted cancer therapies. In this review, we discuss the main known mechanisms of resistance to receptor tyrosine kinase inhibitors, which are the most prevalent class of targeted therapeutic agent in current clinical use. Here we focus on bypass track resistance, which involves the activation of alternate signaling molecules by tumor cells to bypass inhibition and maintain signaling output, and consider the problems of signaling pathway redundancy and how the activation of different receptor tyrosine kinases translates into intracellular signal transduction in different cancer types. This information is presented in the context of research strategies for the discovery of new targets for pharmacological intervention, with the goal of overcoming resistance in order to improve patient outcomes.
关键词: targeted therapy drug resistance receptor tyrosine kinases cancer
Precision medicine in acute lymphoblastic leukemia
Ching-Hon Pui
《医学前沿(英文)》 2020年 第14卷 第6期 页码 689-700 doi: 10.1007/s11684-020-0759-8
关键词: acute lymphoblastic leukemia molecular therapeutics targeted therapy tyrosine kinase inhibitors immunotherapy CAR T-cell therapy
Molecular network-based intervention brings us closer to ending the HIV pandemic
Xiaoxu Han, Bin Zhao, Minghui An, Ping Zhong, Hong Shang
《医学前沿(英文)》 2020年 第14卷 第2期 页码 136-148 doi: 10.1007/s11684-020-0756-y
关键词: human immunodeficiency virus type 1 molecular cluster transmission cluster risk network targeted intervention evaluation
Vaccine therapies for chronic hepatitis B: can we go further?
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《医学前沿(英文)》 2014年 第8卷 第1期 页码 17-23 doi: 10.1007/s11684-014-0313-7
Chronic hepatitis B is a major health burden worldwide. In addition to the recent progress in antiviral treatment, therapeutic vaccination is a promising new strategy for the control of chronic hepatitis B. On the basis of the major specific and non-specific immune dysregulations and defects in chronic hepatitis B patients, this paper presents the peptide and protein-based, DNA-based, cell-based, and antigen-antibody-based therapeutic vaccines, which have undergone clinical trials. The advantages, disadvantages, and future perspectives for these therapeutic vaccines are discussed.
关键词: chronic hepatitis B therapeutic antigen-antibody complexes DNA vaccine
Chimeric antigen receptor T cell therapies for acute myeloid leukemia
Bin Gu, Jianhong Chu, Depei Wu
《医学前沿(英文)》 2020年 第14卷 第6期 页码 701-710 doi: 10.1007/s11684-020-0763-z
《医学前沿(英文)》 2023年 第17卷 第2期 页码 275-289 doi: 10.1007/s11684-022-0945-y
关键词: epidermal growth factor receptor ErbB receptors HM781-36B nasopharyngeal carcinoma molecular targeted therapy cisplatin
Liver cell therapies: cellular sources and grafting strategies
《医学前沿(英文)》 2023年 第17卷 第3期 页码 432-457 doi: 10.1007/s11684-023-1002-1
关键词: liver regeneration hepatocytes cholangiocytes stem cells organoids regulatory mechanisms transplantation/grafting strategies
Influence of Survivin-targeted siRNA on the biological features of colorectal carcinoma cells
XIONG Ying, GUO Wen, LI Ting, LI Ke
《医学前沿(英文)》 2007年 第1卷 第3期 页码 304-307 doi: 10.1007/s11684-007-0058-7
关键词: control therapy influence Survivin-1 colorectal carcinoma
Wen-Can Huang,Wenjie Wang,Wei Wang,Yanan Hao,Changhu Xue,Xiangzhao Mao,
《工程(英文)》 doi: 10.1016/j.eng.2023.05.024
关键词: Polysaccharides Chitosan Hydrogels Oral delivery Intestine-targeted
标题 作者 时间 类型 操作
Molecular markers and pathogenically targeted therapy in non-small cell lung cancer
Bo PENG BA , Jinnong ZHANG MD , Jamile S. WOODS MD , Wei PENG MD, PhD
期刊论文
Molecular targeted therapy of gynecological malignant tumors: the development and challenge, from laboratory
Pengming SUN PhD, MD , Jalid SEHOULI PhD, MD , Lihui WEI BM ,
期刊论文
Synthesis and application of superparamagnetic iron oxide nanoparticles in targeted therapy and imaging
Liangqian Tong, Ming Zhao, Shu Zhu, Jing Chen
期刊论文
Molecular classification of non-small-cell lung cancer: diagnosis, individualized treatment, and prognosis
null
期刊论文
Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies
null
期刊论文
Molecular network-based intervention brings us closer to ending the HIV pandemic
Xiaoxu Han, Bin Zhao, Minghui An, Ping Zhong, Hong Shang
期刊论文
Chimeric antigen receptor T cell therapies for acute myeloid leukemia
Bin Gu, Jianhong Chu, Depei Wu
期刊论文
A small-molecule pan-HER inhibitor alone or in combination with cisplatin exerts efficacy against nasopharyngeal carcinoma
期刊论文
Influence of Survivin-targeted siRNA on the biological features of colorectal carcinoma cells
XIONG Ying, GUO Wen, LI Ting, LI Ke
期刊论文